Synthetic derivatives of aromatic abietane diterpenoids and their biological activities

Miguel A González

doi:10.1016/j.ejmech.2014.10.023

Synthetic derivatives of aromatic abietane diterpenoids and their biological activities

Eur J Med Chem. 2014 Nov 24:87:834-42. doi: 10.1016/j.ejmech.2014.10.023. Epub 2014 Oct 13.

Author

Miguel A González¹

Affiliation

¹ Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Valencia, Spain. Electronic address: Miguel.A.Gonzalez@uv.es.

PMID: 25440884
DOI: 10.1016/j.ejmech.2014.10.023

Abstract

Naturally occurring aromatic abietane diterpenoids (dehydroabietanes) exhibit a wide range of biological activities. A number of synthetic studies aimed at modifying the abietane skeleton in order to obtain new potential chemotherapeutic agents have been reported. In this study, the biological activities of synthetic derivatives of aromatic abietane diterpenoids are reviewed.

Keywords: Abietane; Carnosic acid; Dehydroabietic acid; Dehydroabietylamine; Diterpenoid; Ferruginol.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Molecular Structure

Substances

Diterpenes